Berberine is a natural occurring supplement found to be most effective in modern research and studies. It affects the body at a molecular level and has shown to be effective in lowering blood sugar, causing weight loss, improving heart health and boosts all over immunity. It is one of the few supplements that is found to be as effective as pharmaceutical drugs.
What is Berberine?
Berberine is a bioactive compound extracted from many different plants, including a group of shrubs called Berberis. It’s an alkaloid compound present in the roots, stems, rhizomes, and bark of a variety of plants, including Californian poppy, goldenseal, cork tree, Chinese goldthread, Oregon grape, and several plants in the Berberis genus. It is also widely available as a dietary supplement. Berberine has a long history of use in the ancient and traditional medicine systems of India, China, and Persia.
How does it work?
Berberine has now been tested in hundreds of clinical studies. And it’s shown powerful effects supporting cure of many biological imbalances to support a healthy life. After you take Berberine, it gets taken in your body and is transported into the bloodstream. Then it travels into the body's cells. Inside the cells, it binds to several different “molecular targets” and changes their function. This is similar to how pharmaceutical drugs work.
But the primary mechanism of Berberine revolves around its activation of adenosine monophosphate-activated protein kinase, or AMPK, in multiple cell types, including endothelium, smooth muscle, cardiomyocytes, cancer cells, pancreatic beta cells, hepatocytes, macrophages, and adipocytes. AMPK serves as the master regulator of cellular energy. Its activation influences gene expression and inhibits cellular processes that drive oxidative stress, glucose metabolism, and energy generation in cells.
Preliminary studies have shown that Berberine may have benefits against depression, cancer, infections, fatty liver and heart failure. It also has potent antioxidant and anti-inflammatory effects.
Suggested dosage recommendation is 500 mg, 3 times per day, half an hour before meals. Berberine may cause digestive side effects in some people.