Consuming high amounts of food, particularly fat and sugar, and not burning the energy through exercise and physical activity may cause accumulation of excessive fat in the body leading to obesity. Obesity is associated with skeletal muscle insulin resistance and the development of metabolic syndrome. It can often have psychological, biological, and cultural consequences and sometimes a mix of all.
A lot of Americans struggle with obesity. Rates of obesity in the U.S. have been steadily rising since the 1970s. According to the Centers for Disease Control and Prevention (CDC), more than one-third (35.7 percent) of U.S. adults and almost 17 percent of children aged 2 to 19 years are considered to be obese.
The U.S. adult obesity rates have surpassed the 40% percent mark for the first time is further evidence of the obesity crisis. COVID-19 related food insecurity puts more Americans at risk for obesity or worsening obesity.
Berberine is a potential solution for the prevention and treatment of obesity.
In a recent study published by Elsevier Masson SAS. Berberine is found to have a beneficial impact on gene regulation for the absorption of cholesterol at a daily dose of 300 mg in humans, an amelioration on glucose accumulation at 1.0 g daily dose was also observed.
Berberine suppresses adipocyte differentiation and decreases obesity. It also regulates glucose metabolism via decreasing insulin resistance and increasing insulin secretion.
The above studies give a good account of the impact of Berberine in obesity treatment and prevention.