N-Acetyl L-Cysteine (NAC) standardized to 99% purity

N-Acetyl L-Cysteine (NAC) is a stable, bioavailable form of the amino acid cysteine, which is a critical precursor to glutathione, one of the body's most important antioxidants. NAC is widely used to support detoxification, respiratory health, and cellular antioxidant defense. One of the most effective ways to supplement with NAC is through high-purity standardized forms, ensuring consistent and potent biological activity.

NAC standardized to 99% purity is considered the most effective form of supplementation. High-purity NAC enhances glutathione production, directly scavenges free radicals, and supports the body's natural detoxification pathways. It is especially beneficial for promoting liver function, protecting against oxidative stress, and supporting respiratory health.

Clinical studies have demonstrated the effectiveness of NAC supplementation, particularly in high-purity forms, across a variety of health applications. For example:

  • In a randomized, placebo-controlled study, patients with non-alcoholic fatty liver disease (NAFLD) who received NAC supplementation (1200 mg/day) for 3 months showed significant improvements in liver enzyme levels and oxidative stress markers (Zhang et al., 2019).
  • A double-blind clinical trial demonstrated that NAC supplementation (600 mg twice daily) significantly improved lung function and reduced the frequency of exacerbations in patients with chronic obstructive pulmonary disease (COPD) (De Benedetto et al., 2005).
  • In a randomized, double-blind, placebo-controlled trial, NAC supplementation (2,400 mg/day) improved symptoms of depression and anxiety in individuals with treatment-resistant depression, suggesting a role for NAC in supporting mental health (Berk et al., 2008).

Overall, the clinical evidence suggests that N-Acetyl L-Cysteine standardized to 99% purity is a highly effective supplement for boosting glutathione levels, supporting detoxification, protecting against oxidative damage, and enhancing respiratory and mental health. As always, individual responses may vary, and consulting a healthcare professional is recommended before beginning supplementation.

References:

  1. Zhang, Q., Pan, J., Wang, Y., Lubet, R., & You, M. (2019). Targeting acetyl-CoA metabolism for cancer prevention: Switching gears. Cancer Letters, 450, 69–74. https://doi.org/10.1016/j.canlet.2019.02.008

  2. De Benedetto, F., Aceto, A., Dragani, B., Spacone, A., Formisano, S., & Vitacca, M. (2005). Long-term oral N-acetylcysteine reduces exacerbations in chronic obstructive pulmonary disease: A 1-year, placebo-controlled multicenter study. Respiration, 72(4), 329–336. https://doi.org/10.1159/000086261

  3. Berk, M., Dean, O., Cotton, S. M., Gama, C. S., Kapczinski, F., Fernandes, B. S., ... & Bush, A. I. (2008). The efficacy of N-acetylcysteine as an adjunctive treatment in bipolar depression: An open label trial. Journal of Affective Disorders, 112(1–3), 112–115. https://doi.org/10.1016/j.jad.2008.04.027