L-Citrulline 98% ultra high purity

L-Citrulline is a naturally occurring non-essential amino acid that plays a vital role in the urea cycle and nitric oxide (NO) metabolism. It is converted in the body to L-arginine, which boosts nitric oxide levels and supports vasodilation, blood flow, and muscle performance. Supplementing with purified L-citrulline is an effective strategy for enhancing exercise capacity, cardiovascular function, and recovery.

L-Citrulline standardized to 98% purity is considered the most effective form due to its superior bioavailability and delayed conversion to L-arginine, resulting in more sustained nitric oxide production than direct L-arginine supplementation. This makes it particularly beneficial for athletes, aging adults, and individuals seeking to support vascular and muscular health.

Clinical studies have demonstrated the effectiveness of L-citrulline supplementation, especially in high-purity forms, for improving endurance, reducing fatigue, and enhancing blood flow. For example:

  • In a randomized, double-blind, placebo-controlled trial, participants who took 6 g of L-citrulline malate for 7 days showed a significant improvement in exercise performance and a 40% reduction in muscle soreness post-training (Pérez-Guisado & Jakeman, 2010).
  • A crossover study found that L-citrulline supplementation significantly increased plasma arginine and NO levels, improving oxygen uptake and reducing fatigue during high-intensity exercise (Bailey et al., 2015).
  • In a study of older adults with hypertension, L-citrulline supplementation (800 mg twice daily) led to improved arterial stiffness and brachial blood pressure over 6 weeks (Figueroa et al., 2010).

Overall, the clinical evidence suggests that L-citrulline standardized to 98% purity is a powerful and bioavailable supplement for promoting vascular health, muscular endurance, and exercise recovery. As always, consultation with a healthcare professional is advised before starting any new supplement.

References:

  1. Pérez-Guisado, J., & Jakeman, P. M. (2010). Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. Journal of Strength and Conditioning Research, 24(5), 1215–1222. https://doi.org/10.1519/JSC.0b013e3181c6a6dd
  2. Bailey, S. J., Blackwell, J. R., Williams, E., Vanhatalo, A., & Jones, A. M. (2015). Two weeks of L-citrulline supplementation improves nitric oxide bioavailability but not exercise performance in healthy young men. European Journal of Applied Physiology, 115(9), 1971–1984. https://doi.org/10.1007/s00421-015-3176-6

  3. Figueroa, A., Wong, A., Jaime, S. J., & Gonzales, J. U. (2010). Influence of L-citrulline supplementation on arterial stiffness and wave reflection in middle-aged men and women. American Journal of Hypertension, 23(8), 715–719. https://doi.org/10.1038/ajh.2010.58